Organosulfur Compounds
eMolecules Oakwood Chemicals Tetrahydrothiophene 1kg 480116241 019455 0 000 110-01-0 MFCD00005476 88 170 C4H8S
Oakwood Chemicals Tetrahydrothiophene 1kg 480116241 019455 0 000 110-01-0 MFCD00005476 88 170 C4H8S
eMolecules 4-Cbz-thiomorpholine-3-carboxylic acid | 90471-66-2 | MFCD04114910 | 1g
J & W PharmLab LLC | 4-Cbz-thiomorpholine-3-carboxylic acid | 1g | 532639000 | 53R0035 | 97.000 | 90471-66-2 | MFCD04114910 | 281.330 | C13H15NO4S
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eMolecules Building Block Tool
eMolecules Ambeed / Pyrimidine-2-carbothioamide / 1g / 602851908 / A358147 / / 4537-73-9 / MFCD12093703 / 139.180 / C5H5N3S
Ambeed / Pyrimidine-2-carbothioamide / 1g / 602851908 / A358147 / / 4537-73-9 / MFCD12093703 / 139.180 / C5H5N3S
Medchemexpress LLC MicroRNA modulator-2 | 438599-31-6 | 99.5% | 432.49 g·mol⁻¹ | C23H20N4O3S | 10 MG
MicroRNA modulator-2 is an oxadiazole-class small molecule inhibitor of microRNA-21 (miR-21) with an AC50 of 16.48 μM. Supplied as a solid for research use, it is intended for in vitro miRNA inhibition studies and related cancer research. Molecular formula C23H20N4O3S; molecular weight 432.49 g·mol⁻¹.
- Oxadiazole-class small molecule inhibitor of miR-21.
- AC50 16.48 μM in reported assays.
- High purity (≈99.5%).
- Supplied as a solid; common size 10 mg.
- Suitable for in vitro cellular and biochemical miRNA studies.
- Store at -20°C; for research use only.
AdipoGen 1-Methyltryptamine
Chemical. CAS 7518-21-0. Formula C11H14N2. MW 174.24. Synthetic. Deacetylase inhibitor.
AdipoGen Efavirenz
Chemical. CAS 154598-52-4. Formula C14H9ClF3NO2. MW 315.7. Efavirenz is a non-nucleoside reverse transcriptase inhibitor NNRTI that exhibits antiviral and anticancer activities. Efavirenz binds to wild-type and mutant HIV-1 RTs Ki= 2.93nM and 3.85-56.5nM, respectively. It inhibits wild-type and mutant HIV-1 viral replication in MT-4 human T lymphoid cells IC95s = 1.5-1,500 nM. Efavirenz also prevents RNA plus-strand initiation with an IC50 value of 17nM. Efavirenz is an anti-HIV drug, commonly used in combination therapy for AIDS treatment. It is part of highly active antiretroviral therapy HAART for the treatment of a human immunodeficiency virus HIV type 1. In various cancer cell lines, Efavirenz inhibits cellular proliferation and increases activation of p53. CARD8 inflammasome senses HIV-1 protease activity. In HIV1-infected cells, CARD8 cannot detect the virus because the viral protease remains inactive as a subunit of unprocessed Gag-Pol polyprotein.
AdipoGen Efavirenz
Chemical. CAS 154598-52-4. Formula C14H9ClF3NO2. MW 315.7. Efavirenz is a non-nucleoside reverse transcriptase inhibitor NNRTI that exhibits antiviral and anticancer activities. Efavirenz binds to wild-type and mutant HIV-1 RTs Ki= 2.93nM and 3.85-56.5nM, respectively. It inhibits wild-type and mutant HIV-1 viral replication in MT-4 human T lymphoid cells IC95s = 1.5-1,500 nM. Efavirenz also prevents RNA plus-strand initiation with an IC50 value of 17nM. Efavirenz is an anti-HIV drug, commonly used in combination therapy for AIDS treatment. It is part of highly active antiretroviral therapy HAART for the treatment of a human immunodeficiency virus HIV type 1. In various cancer cell lines, Efavirenz inhibits cellular proliferation and increases activation of p53. CARD8 inflammasome senses HIV-1 protease activity. In HIV1-infected cells, CARD8 cannot detect the virus because the viral protease remains inactive as a subunit of unprocessed Gag-Pol polyprotein.
AdipoGen GS-441524 Remdesivir Metabol
Chemical. CAS 1191237-69-0. Formula C12H13N5O4. MW 291.3. GS-441524 is the active prodrug of the broad-spectrum antiviral Remdesivir. GS-441524 is an adenosine nucleotide analog in viral RNA production. It is a nucleotide analog inhibitor of RNA-dependent RNA polymerases RdRps. The compound interferes with the action of viral RNA polymerase and evades proofreading by viral exoribonuclease ExoN, causing a decrease in viral RNA production RNA synthesis arrest, either by terminating RNA chains or causing mutations. It inhibits MERS-CoV or SARS-CoV-infected HAE cultures EC50=74nM and 69nM and murine hepatitis virus MHV EC50=30nM. In vivo, remdesivir 25 and 50 mg/kg reduces lung viral titers and prevents weight loss in a mouse model of SARS-CoV infection.
AdipoGen 7b-OH-cholesteryl-bishemisucci
Chemical. CAS 105449-93-2. Formula C35H54O8 . 2C2H7NO. MW 602.80 . 61.08. Synthetic Water-soluble derivatives of 7beta-hydroxycholesterol. Anticancer compound, inducing apoptosis in various solid tumor cell lines.
AdipoGen 7b-OH-cholesteryl-bishemisucci
Chemical. CAS 105449-93-2. Formula C35H54O8 . 2C2H7NO. MW 602.80 . 61.08. Synthetic Water-soluble derivatives of 7beta-hydroxycholesterol. Anticancer compound, inducing apoptosis in various solid tumor cell lines.
AdipoGen 4-Hydroxytamoxifen
Chemical. CAS 68392-35-8. Formula C26H29NO2. MW 387.51. 4-Hydroxytamoxifen is an active metabolite of the chemotherapeutic drug tamoxifen, a selective estrogen receptor modulator SERM that acts as an agonist or antagonist in various tissues. 4-Hydroxytamoxifen acts as a tissue-selective agonist-antagonist of the estrogen receptors ERalpha and ERbeta. 4-Hydroxytamoxifen is an isoform-specific inhibitor of orphan estrogen-receptor-related ERR nuclear receptors beta and gamma. 4-Hydroxytamoxifen exhibits anticancer chemotherapeutic activity, inducing autophagy and vacuole formation as well as KRAS degradation in various cancer cell lines. In cardiac myocytes, 4-hydroxytamoxifen decreases Ca2 amplitude, slowing relaxation and decreasing contractility. 4-Hydroxytamoxifen has also shown to be a potent inhibitor of the mitochondrial permeability transition MPT.
Medchemexpress LLC PROTAC degrader targeting Bruton's tyrosine kinase (BTK) | 2416131-46-7 | 99.7% | 719.83 | C39H45N9O5 | 10 MG
NX-2127 is an orally bioavailable PROTAC degrader that targets Bruton's tyrosine kinase (BTK). It induces proteasomal degradation of BTK, shows activity against BTK C481S resistance mutants, degrades IKZF1 and IKZF3 transcription factors, and has demonstrated cellular and in vivo preclinical activity while promoting T cell activation and IL-2 production.
- Orally bioavailable PROTAC degrader of BTK.
- Induces proteasomal degradation of BTK and reduces BTK signaling.
- Active against BTK C481S resistance mutants in cellular models.
- Degrades IKZF1 and IKZF3, providing immunomodulatory effects.
- Stimulates T cell activation and increases IL-2 production in primary human T cells.
- Demonstrated efficacy in preclinical in vivo models.